Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
Autops. Case Rep
; 12: e2021394, 2022. graf
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1393987
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature. It has been categorized as a grade I tumor in the 2021 World Health Organization (WHO) classification central nervous system. Due to the rarity, this meningioma variant origin and biological behavior are still not clear. Immunohistochemistry profile showed prominent PD-L1 expression, leading to additional interrogation on LPRM immunomorphological characteristics, the significance of the inflammatory tumoral microenvironment and its correlation with the immune-checkpoints.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
LILACS
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Autops. Case Rep
Assunto da revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália