Dietary phytate induces subclinical mechanical allodynia in mice
Braz. j. med. biol. res
; 56: e12955, 2023. tab, graf
Article
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LILACS-Express
| LILACS
| ID: biblio-1520478
Biblioteca responsável:
BR1.1
ABSTRACT
Neuropathic pain is a condition with varying origins, including reduced dietary micronutrient intake. Phytate is a polyphosphate found in seeds and grains that can act as an antinutrient due to the ability of sequester essential divalent metals. Here we tested whether moderate dietary phytate intake could alter nociceptive pain. We subjected weaning mice to a chow supplemented with 1% phytate for eight weeks. Body weight gain, glycemic responses, food ingestion, water ingestion, and liver and adipose tissue weights were not altered compared to controls. We observed a decreased mechanical allodynia threshold in the intervention group, although there were no changes in heat- or cold-induced pain. Animals consuming phytate showed reduced spinal cord tumor necrosis factor (TNF), indicating altered inflammatory process. These data provide evidence for a subclinical induction of mechanical allodynia that is independent of phytate consumption in animals with otherwise normal phenotypic pattern.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
LILACS
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil