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Hiperinsulinemia y resistencia insulínica en niños de dos escuelas públicas de Oaxaca, México / Hyperinsulinemia and insulin resistance in children
Rosas-Sumano, Ana Beatriz; Rodal-Canales, Francisco Javier; Barrientos Pérez, Margarita; Cárdenas-Morales, Beatriz Eugenia; Pérez-Campos Mayoral, Laura; Pérez-Campos, Eduardo.
Afiliação
  • Rosas-Sumano, Ana Beatriz; Universidad Autónoma Benito Juárez de Oaxaca. Facultad de Medicina. Centro de investigación médica y biológica (CICIMEBIO). Oaxaca. MX
  • Rodal-Canales, Francisco Javier; Universidad Autónoma Benito Juárez de Oaxaca. Facultad de Medicina. Centro de investigación médica y biológica (CICIMEBIO). Oaxaca. MX
  • Barrientos Pérez, Margarita; Universidad Autónoma Benito Juárez de Oaxaca. Facultad de Medicina. Centro de investigación médica y biológica (CICIMEBIO). Oaxaca. MX
  • Cárdenas-Morales, Beatriz Eugenia; Universidad Autónoma Benito Juárez de Oaxaca. Facultad de Medicina. Centro de investigación médica y biológica (CICIMEBIO). Oaxaca. MX
  • Pérez-Campos Mayoral, Laura; Universidad Autónoma Benito Juárez de Oaxaca. Facultad de Medicina. Centro de investigación médica y biológica (CICIMEBIO). Oaxaca. MX
  • Pérez-Campos, Eduardo; Universidad Autónoma Benito Juárez de Oaxaca. Facultad de Medicina. Centro de investigación médica y biológica (CICIMEBIO). Oaxaca. MX
Rev. méd. Chile ; 144(8): 1020-1028, ago. 2016. graf, tab
Article em Es | LILACS | ID: biblio-830608
Biblioteca responsável: CL1.1
ABSTRACT

Background:

Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood.

Aim:

To measure insulin and glucose levels and parameters of insulin resistance in obese, overweight and normal weight Mexican children. Material and

Methods:

Comparative study of 21 obese children with a body mass index (BMI) over percentile 95, aged 10 ± 1 years (10 males), 14 children aged 10 ± 2 (7 males) with a BMI between percentiles 85 and 94 and 16 children aged 9 ± 2 years (3 males) with a body mass index between percentiles 10 and 84. Body weight, blood pressure and waist circumference were measured and a blood sample was obtained to measure fasting glucose and insulin levels. Homeostasis model of insulin resistance (HOMA) and quantitative insulin sensitivity check index (QUICKI) were calculated.

Results:

Among obese, overweight and normal weight children, insulin levels were 14.9 (95% CI 10.90-18.99), 7.20 (CI 5.12-9.28) and 4.73 (CI 95% 1.92-7.53) uU/ml, respectively. The figures for HOMA were 3.16 (95% CI 2.20-4.12), 1.49 (95% CI 1.03-1.94) and 0.97 (95% CI 0.35-1.60), respectively. The figures for QUICKI were 0.331 (95% CI 0.319-0.343), 0.371 (95% CI 0.349-0.393) and 0.419 (95% CI 0.391-0.446), respectively. Compared to their normal weight counterparts, the risk of obese children and those with a waist circumference over percentile 90 of having a HOMA over 3.16 was 17 and 10 times higher, respectively. BMI correlated better than waist circumference with insulin levels.

Conclusions:

Obese children have higher levels of insulin resistance than their normal weight counterparts.
Assuntos
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Resistência à Insulina / Hiperinsulinismo / Insulina / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies Limite: Child / Female / Humans / Male País/Região como assunto: Mexico Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Resistência à Insulina / Hiperinsulinismo / Insulina / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies Limite: Child / Female / Humans / Male País/Região como assunto: Mexico Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México