Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
An. bras. dermatol
; 93(5): 680-685, Sept.-Oct. 2018. tab
Article
em En
| LILACS
| ID: biblio-949949
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed.Objective:
To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF.Methods:
This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death.Results:
One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR 1.2 / p = 0.004 / 95%CI 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. StudyLimitations:
Small sample and its retrospective analysis.Conclusions:
Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Pele
Base de dados:
LILACS
Assunto principal:
Neoplasias Cutâneas
/
Micose Fungoide
Tipo de estudo:
Guideline
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Brasil