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Protective effect of omega 3 and vitamin D in preventing lung-tissue damage of newborn rats exposed to cigarette smoke during intrauterine period / Efecto protector de omega 3 y vitamina D en la prevención del daño en el tejido pulmonar de ratas recién nacidas expuestas al humo del cigarrillo durante el período intrauterino
Küçük, Zahide; Timur, Burcu; Gözlükgiller, Hayri; Timur, Hakan; Erkenekli, Kudret; Çaydere, Muzaffer; Tokmak, Aytekin.
  • Küçük, Zahide; Yuksek Ihtisas University. Koru Ankara Hospital. Department of Obstetrics and Gynaecology. Ankara. TR
  • Timur, Burcu; Ordu University. Education and Research Hospital. Department of Obsterics and Gynaecology. Ordu. TR
  • Gözlükgiller, Hayri; Altinbas University. Medical Park Bahcelievler Hospital. Department of Pediatrics. Istanbul. TR
  • Timur, Hakan; Ordu University. Education and Research Hospital. Department of Obsterics and Gynaecology. Ordu. TR
  • Erkenekli, Kudret; Zekai Tahir Burak Women's Health Education and Research Hospital. Department of Obstetrics and Gynecology. Ankara. TR
  • Çaydere, Muzaffer; Ankara Education and Research Hospital. Department of Pathology. Ankara. TR
  • Tokmak, Aytekin; Zekai Tahir Burak Women's Health Education and Research Hospital. Department of Obstetrics and Gynecology. Ankara. TR
Int. j. morphol ; 37(1): 87-92, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-990010
Biblioteca responsável: CL1.1
ABSTRACT

SUMMARY:

This study aimed to investigate the toxic effects of cigarette smoke exposure on lung and the protective role of Omega 3 and Vitamin D against these toxic effects biochemically and histologically. 28 pregnant Wistar Albino rats were divided into four groups. The first group was control group; the second group was exposed to smoke of 10 cigarette by puff device 2 hours/day after pregnancy; the third group was exposed to cigarette smoke together with Omega 3 (0.5 mg/kg/day) and the fourth group was exposed to cigarette smoke together with vitamin D (42 microgram/kg/day). Finally, lung tissue sections of the newborn rats were stained with Hemotoxilen eosine and Masson tricromite. Malondialdehyde (MDA) and Fluorescent Oxidation Products (FOU) levels were measured. Fetal weights and the number of fetuses were significantly lower in the group received only cigarette smoke (both p<0.001). Histopathologically, pulmonary volume, number of developed alveols and parenchyma elasticity decreased significantly, meanwhile interstitial tissue increased, elastin and collagen did not develop adequately. Histopathologic changes significantly decreased in the group given Omega 3 and Vitamin D. Statistically, MDA and FOU levels were found to be higher in the group exposed to cigarette smoke compared to the control group, and MDA and FOU levels were lower in the group given Omega 3 along with cigarette smoke (p<0.001). Cigarette smoke caused histologically significant damage to fetal lung tissue, oxidative stress and increased MDA and FOU levels. This damage was significantly reduced with Omega 3 and Vitamine D supplementation. Omega 3 is an important antioxidant; vitamin D has no significant antioxidant effect.
RESUMEN
RESUMEN Este estudio tuvo como objetivo investigar los efectos tóxicos de la exposición al humo de cigarrillo en el pulmón, y el papel protector de Omega 3 y la Vitamina D contra esos efectos. 28 ratas Wistar albino preñadas fueron separadas en cuatro grupos. El primer grupo grupo control; el segundo grupo estuvo expuesto al humo de 10 cigarrillos por dispositivo de inhalación 2 horas / día después de la preñez; el tercer grupo se expuso al humo del cigarrillo junto con Omega 3 (0,5 mg / kg / día) y el cuarto grupo se expuso al humo del cigarrillo junto con vitamina D (42 microgramos / kg / día). Secciones de tejido pulmonar de las ratas recién nacidas se tiñeron con Hematoxilina Eosina y tricrómico de Masson. Se midieron los niveles de malondialdehído (MDA) y productos de oxidación fluorescente (POF). Los pesos fetales y el número de fetos fueron significativamente más bajos en el grupo que recibió solamente humo de cigarrillo (ambos p <0,001). Histopatológicamente, el volumen pulmonar, el número de alveolos desarrollados y la elasticidad del parénquima disminuyeron significativamente; mientras que el tejido intersticial aumentó y la elastina y el colágeno no se desarrollaron adecuadamente. Los cambios histopatológicos disminuyeron significativamente en el grupo que recibió Omega 3 y Vitamina D. Estadísticamente, se encontró que los niveles de MDA y POF eran más altos en el grupo expuesto al humo de cigarrillo en comparación con el grupo control, además los niveles de MDA y POF fueron más bajos en el grupo que recibió Omega 3 junto con el humo del cigarrillo (p <0,001). El humo del cigarrillo causó daños histológicamente significativos en el tejido pulmonar fetal, el estrés oxidativo y el aumento de los niveles de MDA y FOU. Este daño se redujo significativamente con los suplementos de Omega 3 y Vitamina D. El omega 3 es un importante antioxidante; la vitamina D no tiene ningún efecto antioxidante significativo.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Temas: Geral Base de dados: LILACS Assunto principal: Vitamina D / Ácidos Graxos Ômega-3 / Exposição Materna / Lesão Pulmonar / Nicotina Limite: Animais / Gravidez Idioma: Inglês Revista: Int. j. morphol Assunto da revista: Anatomia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Altinbas University/TR / Ankara Education and Research Hospital/TR / Ordu University/TR / Yuksek Ihtisas University/TR / Zekai Tahir Burak Women's Health Education and Research Hospital/TR

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Texto completo: Disponível Coleções: Bases de dados internacionais Temas: Geral Base de dados: LILACS Assunto principal: Vitamina D / Ácidos Graxos Ômega-3 / Exposição Materna / Lesão Pulmonar / Nicotina Limite: Animais / Gravidez Idioma: Inglês Revista: Int. j. morphol Assunto da revista: Anatomia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Altinbas University/TR / Ankara Education and Research Hospital/TR / Ordu University/TR / Yuksek Ihtisas University/TR / Zekai Tahir Burak Women's Health Education and Research Hospital/TR