Clinical outcome of sodium alginate therapy in radiation-induced pharyngeal mucositis: experience of a single Japanese institution
Appl. cancer res
; 39: 1-5, 2019. ilus, tab
Artigo
em Inglês
| LILACS, Inca
| ID: biblio-997737
Biblioteca responsável:
BR30.1
Localização: BR30.1
ABSTRACT
Purpose:
We investigated the clinical outcome of sodium alginate treatment in radiation-induced pharyngeal mucositis (RIPM) after neck irradiation. Materials andmethods:
The study population included 32 patients (11 lung cancer, 10 breast cancer, 7 head and neck cancer, and 4 other primary lesions) who underwent neck external beam radiotherapy at the authors' institution between June 2006 and 2016. The patients received 5% sodium alginate solution orally for RIPM. Those who were followed up for less than 2 months or did not receive 5% sodium alginate were excluded from this retrospective study. RIPM was graded weekly as an acute toxicity according to the Common Terminology Criteria for Adverse Events (CTCAE), version 4. The administration of 10-15 ml of sodium alginate before each meal was continued until the radiotherapy was completed and after resolution of odynophagia. The efficacy of sodium alginate was assessed by two radiation oncologists as follows Grade I, ineffective; grade II, moderately effective; grade III, very effective. When sodium alginate was ineffective, other analgesics, such as nonsteroidal antiinflammatory drugs (NSAIDS) or opioids, were added. Relationships between the presence/absence of additional analgesics and the radiation dose were investigated.Results:
The median duration from the start of irradiation to sodium alginate administration was 15 days (range, 536 days). RIPM improved in 29/32 patients (grade II, n = 22; III, n = 7). Three patients showed no improvement. No sodium alginate-related toxicities occurred. Additional analgesics were required in 5/32 patients. The radiation dose in these 5 patients was significantly higher than that in the sodium alginate-alone group (63.6 ± 7.8 Gy vs 48.3 ± 14.8Gy, P = 0.02). Patients who received > 50 Gy tended to require additional analgesics more frequently than those who received ≤50Gy (P = 0.10).Conclusions:
The concurrent administration of sodium alginate and neck irradiation was feasible and tolerable without obvious toxicities. Under certain conditions sodium alginate could be a promising alternative to NSAIDs and opioids in RIPM. The results justify further prospective evaluations with detailed treatment protocols to clarify whether sodium alginate can improve RIPM (AU)
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Temas:
Geral
/
Prevenção e Fatores de Risco
/
Agentes Cancerígenos
/
Tratamento
/
Radioterapia
Base de dados:
LILACS
/
PrevCan
Assunto principal:
Faringe
/
Alginatos
/
Mucosite
Tipo de estudo:
Etiology_studies
/
Guia de prática clínica
/
Observational_studies
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Japão
Instituição/País de afiliação:
Kitakyushu General Hospital/JP
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