Oral Candida flora from Brazilian human immunodeficiency virus-infected patients in the highly active antiretroviral therapy era
Mem. Inst. Oswaldo Cruz
; 99(4): 425-431, Jun. 2004. tab
Article
em En
| LILACS
| ID: lil-363862
Biblioteca responsável:
BR1.1
RESUMO
One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90 percent of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8 percent were identified as Candida albicans and 42.1 percent as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5 percent), C. lusitaniae (5.2 percent), C. tropicalis (4.6 percent), C. parapsilosis (4.6 percent), C. glabrata (2.8 percent), C. kefyr (1.7 percent), C. guilliermondii (1.7 percent), C. intermedia (1.1 percent), C. norvegensis (0.5 percent), and Rhodotorula rubra (1.7 percent). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 æg/ml). This study revealed huge diversity of Candida species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Candida
/
Candidíase Bucal
/
Infecções por HIV
/
Infecções Oportunistas Relacionadas com a AIDS
/
Terapia Antirretroviral de Alta Atividade
/
Antifúngicos
Tipo de estudo:
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
/
Japão