Involvement of nitric oxide pathways in neurogenic pulmonary edema induced by vagotomy
Clinics
; 66(6): 1061-1066, 2011. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-594379
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the involvement of peripheral nitric oxide (NO) in vagotomy-induced pulmonary edema by verifying whether the nitric oxide synthases (NOS), constitutive (cNOS) and inducible (iNOS), participate in this mechanism.INTRODUCTION:
It has been proposed that vagotomy induces neurogenic pulmonary edema or intensifies the edema of other etiologies.METHODS:
Control and vagotomized rats were pretreated with 0.3 mg/kg, 3.0 mg/kg or 39.0 mg/kg of L-NAME, or with 5.0 mg/kg, 10.0 mg/kg or 20.0 mg/kg of aminoguanidine. All animals were observed for 120 minutes. After the animals' death, the trachea was catheterized in order to observe tracheal fluid and to classify the severity of pulmonary edema. The lungs were removed and weighed to evaluate pulmonary weight gain and edema index.RESULTS:
Vagotomy promoted pulmonary edema as edema was significantly higher than in the control. This effect was modified by treatment with L-NAME. The highest dose, 39.0 mg/kg, reduced the edema and prolonged the survival of the animals, while at the lowest dose, 0.3 mg/kg, the edema and reduced survival rates were maintained. Aminoguanidine, regardless of the dose inhibited the development of the edema. Its effect was similar to that observed when the highest dose of L-NAME was administered. It may be that the non-selective blockade of cNOS by the highest dose of L-NAME also inhibited the iNOS pathway.CONCLUSION:
Our data suggest that iNOS could be directly involved in pulmonary edema induced by vagotomy and cNOS appears to participate as a protector mechanism.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Edema Pulmonar
/
Vagotomia
/
Óxido Nítrico Sintase Tipo II
/
Óxido Nítrico Sintase Tipo III
/
Óxido Nítrico
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of São Paulo/BR
/
Universidade Estadual de Londrina/BR
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