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Effects of castration and antiandrogens (RU 23908 and cyproterone acetate) on glandulan activity and on the secretory epithelium of the rat submandibular gland
Braz. j. med. biol. res ; 21(3): 591-8, Mar. 1988. tab
Article em En | LILACS | ID: lil-60270
Biblioteca responsável: BR1.1
RESUMO
The influence of hormones on the submandibular gland of rodents has attracted more attention since the observation of the sexual dimorphism of these organs. Androgens enhance both the development and secretory activity of the gland. In the present investigation we have studied the differences in wet weight, protein content, glandulain activity and morphometry of granular convoluted tubules of submandibular glands excised from control, castrated and antiandrogen-teated (RU 23908 or cyproterone acetate) male adult albino rats. Castration and antiandrogenic treatment did not affect the wet weight or protein content of the organs. Castration or treatment with RU 23908, but not treatment with cyproterone acetate, decreased glandulain activity and the height of the secretory epithelium of granular ducts. The morphology and glandulain activity of submandibular gland granular ducts do not seem to be related solely to plasma testosterone concentration. Different hormonal treatments are needed to identify other factors implicated in the phenomenon
Assuntos
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Glândula Submandibular / Castração / Caracteres Sexuais / Antagonistas de Androgênios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1988 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Glândula Submandibular / Castração / Caracteres Sexuais / Antagonistas de Androgênios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1988 Tipo de documento: Article