Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación / Evaluation of embryotoxicity of misoprostol using the whole embryo culture assay
Rev. méd. Chile
; 139(5): 613-617, mayo 2011. ilus, tab
Article
em Es
| LILACS
| ID: lil-603098
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
Approximately 15 percent of misoprostol-induced-abortions may not be successful, leading to in utero exposure to the drug and to the induction of a series of defects including central nervous system, limb and visceral defects. A commonproposal is that the drug causes disruption of the fetal vasculature leading to embryonic or fetal hypoxia.Aim:
To evaluate the teratogenicity of misoprostol using the rat post-implantation embryo culture. Material andMethods:
Rat embryos were collected at the beginning of organogenesis and cultured in rat serum containing misoprostol at concentrations of 200, 2,000 or 20,000 pg/ml. Functionality, morphology and morphometry parameters were evaluated.Results:
Misoprostol induced a dose-dependent embryotoxic effect causing a decrease in embryo viability and function (poor vascular development and survival) and morphometry (alterations in branchial arches, heart and cephalic portions of the neural tube, among others).Conclusions:
All the manifestations observed are indicative of the ability of misoprostol to directly induce developmental retardation and alterations.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Anormalidades Induzidas por Medicamentos
/
Abortivos não Esteroides
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Misoprostol
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Embrião de Mamíferos
Limite:
Animals
/
Pregnancy
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article
/
Project document
País de afiliação:
Chile