6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure
Psychol. neurosci. (Impr.)
; 7(2): 233-241, Jan.-June 2014. graf, tab
Article
em En
| LILACS
| ID: lil-718329
Biblioteca responsável:
BR85.1
ABSTRACT
Impaired temporal control is symptomatic of several neurological disorders; recently, it has been implicated in schizophrenia. An animal model of schizophrenia using 6-hydroxydopamine (6-OHDA) infused to the medial pre-frontal cortex (mPFC) was employed to examine its effects on temporal control. Twelve rats were trained on a peak-interval procedure (PIP) until stable patterns of behavior were obtained. Rats infused with 6-OHDA responded less during peak trials and their peak functions were flatter than sham rats. These results are consistent with similar studies with transgenic mice with increased striatal dopamine D2 receptor activity. Lesions in the mPFC decreased motivation to respond in a PIP. These effects may be considered analogous to negative symptoms of schizophrenia...
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Esquizofrenia
/
Oxidopamina
Limite:
Animals
Idioma:
En
Revista:
Psychol. neurosci. (Impr.)
Assunto da revista:
NEUROLOGIA
/
PSICOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos