Oxidative stress is attenuated in mice overexpressing BCL-2.
Neurosci Lett
; 262(1): 33-6, 1999 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-10076866
ABSTRACT
The protooncogene Bcl-2 inhibits apoptosis in neural cells, which may involve mitochondrial stabilization and decreased generation of reactive oxygen species. Using in vivo microdialysis we found that following administration of the mitochondrial toxin 3-nitropropionic acid (3-NP) there was a significant increase in the conversion of 4-hydroxybenzoic acid (4-HBA) to 3,4-dihydroxybenzoic acid (3,4-DHBA) in control mice, but not in Bcl-2 overexpressing mice. Striatal lesions were observed in littermate control mice, whereas, lesions were minimal or absent in Bcl-2 overexpressing mice. This shows that Bcl-2 overexpression in vivo attenuates the generation of reactive oxygen species.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Proteínas Proto-Oncogênicas c-bcl-2
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos