31P MRS studies of exercising human muscle at high temporal resolution.
Magn Reson Med
; 41(6): 1145-51, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10371446
ABSTRACT
Methods for measuring mitochondrial activity from 31P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non-exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Qmax calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Contração Isométrica
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Magn Reson Med
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos