Management of males with 45,X/46,XY gonadal dysgenesis.
Horm Res
; 52(1): 11-4, 1999.
Article
em En
| MEDLINE
| ID: mdl-10640893
Males with the 45,X/46,XY karyotype and malformations of the external genitalia carry an increased risk of developing germ cell neoplasia of the gonads. We have studied gonadal tissue from 10 individuals, 0.3-17 years of age, with a male phenotype and either hypospadias and/or cryptorchidism. Four patients, 0.3-15 years of age, had carcinoma in situ, 1 boy had Sertoli-cell-only pattern and the remainder prepubertal histology. Gonadoblastoma or invasive carcinoma was not found. On the basis of our current knowledge we propose a strategy for management and follow-up of these boys in order to detect possible premalignant histological changes early and prevent development of a gonadal tumour.
Buscar no Google
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Disgenesia Gonadal
Limite:
Adolescent
/
Adult
/
Child
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Horm Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Dinamarca