Cognitive functioning after subthalamic nucleotomy for refractory Parkinson's disease.
J Neurol Neurosurg Psychiatry
; 69(1): 60-6, 2000 Jul.
Article
em En
| MEDLINE
| ID: mdl-10864605
ABSTRACT
OBJECTIVE:
To evaluate whether subthalamic nucleotomy produces adverse cognitive effects in patients with Parkinson's disease.METHOD:
Twelve patients with Parkinson's disease underwent stereotactic surgery to the subthalamic nucleus. Presurgical and postsurgical neuropsychological assessment of attention, memory, executive function, language, and verbal intellect were undertaken with a battery of tests designed to minimise potential contamination of cognitive effects by motor symptoms.RESULTS:
There was no statistically significant difference in the cognitive tests results after operation for the group as a whole. Reliable change indexes were generated for the cognitive tests. Reliable change postoperatively was found on specific tests of verbal memory, attention, and planning. Left sided operations were associated with greater incidence of deterioration postsurgery.CONCLUSIONS:
Preliminary data on the first reported cognitive changes after subthalamic nucleotomy suggested few adverse cognitive effects of the surgery although discrete neuropsychological changes were seen in some patients. These effects were consistent with current theories on the cognitive functions of the basal ganglia.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Complicações Pós-Operatórias
/
Transtornos Cognitivos
/
Núcleo Subtalâmico
/
Testes Neuropsicológicos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Reino Unido