[A new pentanucleotide STR-marker, located in the intron of the ING1 tumor suppressor gene and its allelic polymorphism]. / Novyi pentanukleotidnyi STR-marker, raspolozhennyi v introne gena-suppressora opukholevogo rosta ING1 i ego allel'nyi polimorfizm.
Genetika
; 37(1): 117-9, 2001 Jan.
Article
em Ru
| MEDLINE
| ID: mdl-11234417
ABSTRACT
DNA samples of unrelated subjects from the Volga-Ural region of Russia were examined to study allele polymorphism of the pentanucleotide repeat (TTGTG)8 localized to an intron of the tumor suppressor gene ING1. STR marker was registered in the EMBL database with the accession number AJ277387. In a sample of 119 individuals, three pentanucleotide alleles consisting of seven, eight, and nine repeated monomers were revealed. The allele frequencies were 0.24, 0.74, and 0.02, respectively. Heterozygosity was 0.45. On the basis of these data, the repeat can be regarded as a polymorphic STR marker for the ING1 gene and used in population and clinical studies.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Polimorfismo Genético
/
Íntrons
/
Proteínas
/
Marcadores Genéticos
/
Genes Supressores de Tumor
/
Alelos
Idioma:
Ru
Revista:
Genetika
Ano de publicação:
2001
Tipo de documento:
Article