Pluraflavins, potent antitumor antibiotics from Saccharothrix sp. DSM 12931.
J Antibiot (Tokyo)
; 54(9): 718-29, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11714228
ABSTRACT
The new pluramycin-type antibiotics pluraflavin A, C43H54N2O14, pluraflavin B, C43H56N2O15, and pluraflavin E, C36H41NO14 were isolated from cultures of the Saccharothrix species DSM 12931. The structures of the novel compounds were elucidated with the aid of 2D NMR and mass spectrometric investigations. The characteristic structural element of pluraflavins A and B is an additional 4-epi-vancosamine unit at position 13 of the anthraquinone-gamma-pyrone ring system. Pluraflavin E has a carboxyl group in this position. Pluraflavin A has a reactive dimethyl epoxide side chain at position 2 of the anthraquinone-gamma-pyrone aglycon, which may explain the high activity of the antibiotic. The outstanding biological characteristic of pluraflavin A is its powerful, organ-dependent cytostatic action the IC50 in the colon carcinoma proliferation assay is in the subnanomolar range.
Buscar no Google
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Actinomycetales
/
Divisão Celular
/
Antraquinonas
/
Antibióticos Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha