Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat?
Neuroreport
; 12(18): 3989-91, 2001 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-11742225
ABSTRACT
Testosterone alters the expression of proopiomelanocortin (POMC) mRNA in the neurons of the arcuate nucleus. While observations suggest that both estrogen and androgen receptors (AR) can mediate this action, only a negligible number of POMC neurons has previously been shown to contain estrogen receptor (ER)-alpha. To determine whether the putative action of testosterone is mediated via ER-beta or AR we double immuno- labeled hypothalamic sections from colchicine-pretreated male rats. Only few cells were immunostained for ER-beta and they were never found to co-localize POMC. In spite of the overlap in the anatomical distribution, only 3% of POMC cells appeared to contain AR. These results suggest that sex steroids have an indirect effect on most POMC neurons.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Núcleo Arqueado do Hipotálamo
/
Pró-Opiomelanocortina
/
Receptores Androgênicos
/
Receptores de Estrogênio
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Holanda