Your browser doesn't support javascript.
loading
Non-antisense cellular responses to oligonucleotides.
Anselmet, Alain; Mayat, Ebrahim; Wietek, Stefan; Layer, Paul G; Payrastre, Bernard; Massoulié, Jean.
Afiliação
  • Anselmet A; CNRS UMR 8544, Laboratoire de Neurobiologie, Ecole Normale Supérieure, Paris, France. anselmet@biologie.ens.fr
FEBS Lett ; 510(3): 175-80, 2002 Jan 16.
Article em En | MEDLINE | ID: mdl-11801249
Oligonucleotides induce various cellular responses which are not due to the blockade of protein synthesis by an antisense mechanism. Oligonucleotides presenting double-stranded or G-quartet structures (ribo- or deoxyribonucleotides, phosphodiester or phosphorothioated) induce retraction of neurites and aggregation of chicken retinal cells within 10-20 h. This effect is reversible, non-toxic; it appears to require internalization and can be mimicked by treatment of the cells with an RGDS peptide. The oligonucleotides appear to trigger a cascade of intracellular events, affecting the adhesive properties of integrins. In addition, a subset of oligonucleotides induced platelet aggregation, probably through their interaction with membrane receptors. Recognition of these effects is important for the design and interpretation of antisense experiments.
Assuntos
Buscar no Google
Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Retina / Agregação Plaquetária Limite: Animals / Humans Idioma: En Revista: FEBS Lett Ano de publicação: 2002 Tipo de documento: Article País de afiliação: França
Buscar no Google
Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Retina / Agregação Plaquetária Limite: Animals / Humans Idioma: En Revista: FEBS Lett Ano de publicação: 2002 Tipo de documento: Article País de afiliação: França