Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats.
Neurosci Lett
; 321(3): 137-40, 2002 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-11880191
ABSTRACT
Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain. On postnatal day 14 (P14), four groups of rats intraperitoneally received saline, aminophylline, lithium--pilocarpine (Li-PC), and Li-PC plus aminophylline, respectively. Subsequently, the Morris water maze task was performed at P80. The brains were then analyzed with cresyl violet stain for histological lesions and evaluated for mossy fiber sprouting with the Timm stain. No seizures were elicited in the saline-treated or aminophylline-treated rats. Both the Li-PC-treated and aminophylline plus Li-PC-treated rats exhibited seizures and there was no significant difference in mortality between the two groups. More interestingly, as in adulthood (P80), aminophylline aggravated the spatial deficits and histological damages seen in Li-PC-treated rats. In summary, this present study suggests that the use of adenosine receptor antagonists, such as aminophylline, exacerbates seizure-induced damage in the developing brain.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
/
Estado Epiléptico
/
Transtornos Cognitivos
/
Antagonistas de Receptores Purinérgicos P1
/
Aminofilina
/
Hipocampo
/
Degeneração Neural
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Taiwan