[High plasma levels of factor VIII and von Willebrand factor in a patient with portal vein thrombosis]. / Pfortaderthrombose bei einem Patienten mit erhöhtem Faktor-VIII-Spiegel und von-Willebrand-Faktor.
Z Gastroenterol
; 40(6): 409-12, 2002 Jun.
Article
em De
| MEDLINE
| ID: mdl-12055664
ABSTRACT
In portal vein thrombosis, various hypercoagulable conditions and inherited or acquired thrombophilias have already been described as predisposing factors. In a 33-year-old man admitted to a hospital with upper abdominal pain, a partial portal vein and upper mesenteric vein thrombosis, respectively, and a complete splenic vein thrombosis were diagnosed. Further diagnostic procedures showed no evidence for local precipitating factors or any underlying infectious, paraneoplastic or inflammatory disease. Thrombophilia screening demonstrated elevated factor VIII levels (206 %) and von Willebrand factor levels (> 440 %). An acute-phase reaction was excluded. Oral anticoagulant therapy with phenprocoumon was started. Factor VIII and von Willebrand factor were reproducibly elevated to high activity levels over a period of 12 months in absence of acute or chronic inflammatory reaction. Increased levels of factor VIII and von Willebrand factor may play a pathogenetic role in the development of portal, splenic, and mesenteric thrombosis.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Veia Porta
/
Trombose
/
Fator VIII
/
Fator de von Willebrand
/
Trombofilia
/
Oclusão Vascular Mesentérica
/
Veias Mesentéricas
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
De
Revista:
Z Gastroenterol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Alemanha