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Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis.
Moody, Susan E; Sarkisian, Christopher J; Hahn, Kristina T; Gunther, Edward J; Pickup, Steven; Dugan, Katherine D; Innocent, Nathalie; Cardiff, Robert D; Schnall, Mitchell D; Chodosh, Lewis A.
Afiliação
  • Moody SE; Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Cancer Cell ; 2(6): 451-61, 2002 Dec.
Article em En | MEDLINE | ID: mdl-12498714
To determine the impact of tumor progression on the reversibility of Neu-induced tumorigenesis, we have used the tetracycline regulatory system to conditionally express activated Neu in the mammary epithelium of transgenic mice. When induced with doxycycline, bitransgenic MMTV-rtTA/TetO-NeuNT mice develop multiple invasive mammary carcinomas, essentially all of which regress to a clinically undetectable state following transgene deinduction. This demonstrates that Neu-initiated tumorigenesis is reversible. Strikingly, extensive lung metastases arising from Neu-induced mammary tumors also rapidly and fully regress following the abrogation of Neu expression. However, despite the near universal dependence of both primary tumors and metastases on Neu transgene expression, most animals bearing fully regressed Neu-induced tumors ultimately develop recurrent tumors that have progressed to a Neu-independent state.
Assuntos
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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Indução de Remissão / Adenocarcinoma / Transformação Celular Neoplásica / Genes erbB-2 / Neoplasias Pulmonares / Neoplasias Mamárias Experimentais Limite: Animals Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Indução de Remissão / Adenocarcinoma / Transformação Celular Neoplásica / Genes erbB-2 / Neoplasias Pulmonares / Neoplasias Mamárias Experimentais Limite: Animals Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Estados Unidos