Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis.
Arthritis Rheum
; 48(6): 1701-7, 2003 Jun.
Article
em En
| MEDLINE
| ID: mdl-12794839
ABSTRACT
OBJECTIVE:
To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis.METHODS:
Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored.RESULTS:
Systemic delivery of CpG ODNs significantly increased susceptibility to local inflammation, whereas systemic treatment with suppressive ODNs reduced this susceptibility. CD11c+ cells played a key role in mediating host sensitivity to arthritis. These cells were the dominant source of tumor necrosis factor alpha production in CpG-stimulated animals and transferred resistance to arthritis from mice treated with suppressive ODNs.CONCLUSION:
Systemic exposure to immunostimulatory and immunosuppressive DNA influences host susceptibility to local inflammatory challenge. Current findings raise the possibility that suppressive ODNs may be useful in the prevention/treatment of proinflammatory diseases.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Artrite Experimental
/
Adjuvantes Imunológicos
/
Artrite Reativa
/
Ilhas de CpG
/
Suscetibilidade a Doenças
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Arthritis Rheum
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Alemanha