Examination of soluble Fas (sFas) and soluble Fas ligand (sFasL) in patients with burns.
Burns
; 29(8): 799-802, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14636754
ABSTRACT
The FasL-Fas system is one of the recognized apoptosis-inducing systems, and has been determined to have important functions in relation to homeostasis and biological defense mechanisms. In this study, we investigated the serum levels of soluble Fas (sFas), soluble FasL (sFasL) and tumor necrosis factor alpha (TNF-alpha) in patients with burns. The sFas levels were found to be significantly higher in the patients who eventually died as compared to those in the patients who survived (3.9+/-1.8ng/ml versus 2.6+/-1.0ng/ml). On the other hand, the sFasL levels were significantly higher in the patients who survived (61.5+/-29.9ng/ml versus 37.2+/-14.4ng/ml) than in those who eventually died. A positive correlation was noted between the TNF-alpha level and the sFas level, and a negative correlation was observed between the TNF-alpha level and the sFasL level. These findings suggest that worsening of the condition of a burns patient may be related to changes in the Fas-FasL system.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Queimaduras
/
Glicoproteínas de Membrana
/
Receptor fas
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Burns
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão