Mucociliary clearance is enhanced in rat models of cigarette smoke and lipopolysaccharide-induced lung disease.
Exp Lung Res
; 30(1): 59-71, 2004.
Article
em En
| MEDLINE
| ID: mdl-14967604
ABSTRACT
In this study, the authors describe a new technique enabling the rapid assessment of mucociliary clearance (MCC) in rats and characterize this aspect of innate host defense in 2 animal models of bronchitis. Following instillation into the airways, fluorescent microspheres were rapidly cleared over 24 hours, with 60% to 80% of clearance occurring within 4 hours. On a background of airway neutrophilia and mucus hypersecretion, induced by either lipopolysaccharide or cigarette smoke, MCC was significantly enhanced. This reserve capacity in the MCC system will need to become overwhelmed in order to model the clinically observed impairment of lung mucus clearance in an animal system.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Bronquite
/
Fumar
/
Lipopolissacarídeos
/
Depuração Mucociliar
Limite:
Animals
Idioma:
En
Revista:
Exp Lung Res
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido