In vitro gender differences in neuronal survival on hypoxia and in 17beta-estradiol-mediated neuroprotection.
J Cereb Blood Flow Metab
; 25(4): 427-30, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15689954
ABSTRACT
Gender differences in neuropsychiatric disease are recognized but not well understood. Investigating the survival of primary rat hippocampal neurons in culture, we found significant and inverted gender differences on normoxia versus hypoxia. Male cells were more resistant under normoxia but more vulnerable under hypoxia than female cells. Male vulnerability pattern was acquired in cells from neonatally testosterone-primed females. Estrogens, acting via membrane receptors, had a higher neuroprotective power in male neurons, explained at least in part by the pronounced increase in estrogen receptor beta/alpha ratio during hypoxia in male cells only.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Hipóxia Encefálica
/
Fármacos Neuroprotetores
/
Estradiol
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Alemanha