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Long term hematologic recovery after autologous stem cell transplantation in lymphoma patients: impact of the number of prefreeze and post-thaw CD34+ cells.
Mounier, Nicolas; Larghero, Jérome; Manson, Julien; Brice, Pauline; Madelaine-Chambrin, Isabelle; Brière, Josette; Ertault, Marjane; Hennequin, Christophe; Miclea, Jean-Michel; Benbunan, Marc; Marolleau, Jean-Pierre; Gisselbrecht, Christian.
Afiliação
  • Mounier N; Institut universitaire d'hématologie, Hôpital Saint-Louis, Inserm ERM 0220, 1, avenue Claude-Vellefaux, 75010 Paris, France. nicolas.mounier@sls.ap-hop-paris.fr
Bull Cancer ; 92(3): E31-8, 2005 Mar.
Article em En | MEDLINE | ID: mdl-15820915
BACKGROUND: Autologous Stem Cell Transplantation (ASCT) with Peripheral Blood Stem Cells is widely used as consolidation in lymphoma patients. The rapidity and stability of cell engraftment correlate with the number of CD34+ cells in the autograft. However, whether CD34+ cells should be quantified before or after cryopreservation remains unclear. PATIENTS AND METHODS: Of 173 consecutive patients who underwent ASCT in our department from Nov 1, 1995 to Nov 1, 2000, 133 (78 %) were alive without relapse at one year. We report here the results for 106 patients whose hematologic data were available. RESULTS: At one year, the hemoglobin was normal in 47% of the patients, the leukocytes, in 77% and the platelets, in 60%. Only 33% had a normal blood count. We observed a significant correlation between prefreeze and post-thaw CD34+ cell numbers (r = 0.77). However, multivariate analysis using the Cox model with smoothing splines to assess the best cut-off point for these numbers demonstrated that the only independent predictive factor for a normal blood count after one year was a prefreeze number of CD34+ cells above 5.10(6)/kg. CONCLUSION: An optimal long-term hematologic recovery after ASCT required a number of prefreeze CD34+ cells of at least 5.10(6)/kg.
Assuntos
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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Doença de Hodgkin / Transplante de Células-Tronco Hematopoéticas / Antígenos CD34 Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Bull Cancer Ano de publicação: 2005 Tipo de documento: Article País de afiliação: França
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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Doença de Hodgkin / Transplante de Células-Tronco Hematopoéticas / Antígenos CD34 Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Bull Cancer Ano de publicação: 2005 Tipo de documento: Article País de afiliação: França