Successful hormone treatment of orbital leiomyoma.

PURPOSE: To describe the successful hormone treatment of noncircumscribed orbital leiomyoma. DESIGN: Case report. PARTICIPANT: A 66-year-old woman with histologically proven orbital leiomyoma. METHODS: Because surgical excision of the tumor was impossible, therapy with the gonadotropin-releasing hormone (GnRH) analog goserelin was performed. RESULTS: Hormone treatment was well tolerated and no side effects were noted. The tumor regressed significantly during treatment. No recurrence occurred during a 5-year follow-up period. CONCLUSIONS: This report describes for the first time successful hormone treatment of a noncircumscribed orbital leiomyoma. Goserelin may have an antiproliferative effect on leiomyoma cells via membrane receptors for GnRH.