New cytotoxic isoflavone from the root bark of Brosimum utile.
Nat Prod Res
; 19(4): 331-5, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15938138
ABSTRACT
A new isoflavone 5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Raízes de Plantas
/
Moraceae
/
Casca de Planta
/
Isoflavonas
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália