Short-term regulation of the alpha-ketoglutarate dehydrogenase complex by energy-linked and some other effectors.
Biochemistry (Mosc)
; 70(7): 726-9, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-16097935
ABSTRACT
The question of regulation of alpha-ketoglutarate dehydrogenase complex (KGDHC) has been considered in the biochemical literature very rarely. Moreover, such information is not usually accurate, especially in biochemical textbooks. From the mini-review of research works published during the last 25 years, the following basic view is clear a) animal KGDHC is very sensitive to ADP, P(i), and Ca2+; b) these positive effectors increase manifold the affinity of KGDHC to alpha-ketoglutarate; c) KGDHC is inhibited by ATP, NADH, and succinyl-CoA; d) the ATP effect is realized in several ways, probably mainly via opposition versus ADP activation; e) NADH, besides inhibiting dihydrolipoamide dehydrogenase component competitively versus NAD+, decreases the affinity of alpha-ketoglutarate dehydrogenase to substrate and inactivates it; f) thioredoxin protects KGDHC from self-inactivation during catalysis; g) bacterial and plant KGDHC is activated by AMP instead of ADP. These main effects form the basis of short-term regulation of KGDHC.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Metabolismo Energético
/
Complexo Cetoglutarato Desidrogenase
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Polônia