Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities.
Antimicrob Agents Chemother
; 49(10): 4093-100, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16189085
ABSTRACT
The increased incidence of human immunodeficiency virus (HIV)/AIDS disease in women aged 15 to 49 years has identified the urgent need for a female-controlled, efficacious, and safe vaginal topical microbicide. To meet this challenge, sophorolipid (SL) produced by Candida bombicola and its structural analogs have been studied in this report for their spermicidal, anti-HIV, and cytotoxic activities. The sophorolipid diacetate ethyl ester derivative is the most potent spermicidal and virucidal agent of the series of SLs studied. Its virucidal activity against HIV and sperm-immobilizing activity against human semen are similar to those of nonoxynol-9. However, it also induced enough vaginal cell toxicity to raise concerns about its applicability for long-term microbicidal contraception. Its structure-activity relationship has been established for creating new analogs with less cytotoxicity and higher activity.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Motilidade dos Espermatozoides
/
Espermicidas
/
Glicolipídeos
/
Fármacos Anti-HIV
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos