Focal adhesion molecules as potential target of lead toxicity in NRK-52E cell line.
FEBS Lett
; 579(27): 6251-8, 2005 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-16253243
ABSTRACT
In this study, we investigated the influence of inorganic lead (Pb(II)), an environmental pollutant having nephrotoxic action, on the focal adhesion (FA) organization of a rat kidney epithelial cell line (NRK-52E). In particular, we evaluated the effects of the metal on the recruitment of paxillin, focal adhesion kinase, vinculin and cytoskeleton proteins at the FAs complexes. We provided evidences that, in proliferating NRK-52E cell cultures, low concentrations of Pb(II) affect the cell adhesive ability and stimulate the disassembly of FAs, thus inhibiting the integrin-activated signalling. These effects appeared to be strictly associated to the Pb-induced arrest of cell cycle at G0/G1 phase also proved in this cell line.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Adesões Focais
/
Proteínas do Citoesqueleto
/
Poluentes Ambientais
/
Rim
/
Chumbo
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália