Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 61(Pt 1): 118-20, 2005 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-16508109
ABSTRACT
Inhibitors of the enzyme catechol-O-methyltransferase (COMT) are used as co-adjuvants in the therapy of Parkinson's disease. A recombinant form of the soluble cytosolic COMT from rat has been co-crystallized with a new potent inhibitor, BIA 8-176 [(3,4-dihydroxy-2-nitrophenyl)phenylmethanone], by the vapour-diffusion method using PEG 6K as precipitant. Crystals diffract to 1.6 A resolution on a synchrotron-radiation source and belong to the monoclinic space group P2(1), with unit-cell parameters a = 52.77, b = 79.63, c = 61.54 A, beta = 91.14 degrees.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Catecol O-Metiltransferase
/
Inibidores Enzimáticos
/
Inibidores de Catecol O-Metiltransferase
Limite:
Animals
Idioma:
En
Revista:
Acta Crystallogr Sect F Struct Biol Cryst Commun
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Portugal