NAP, a peptide derived from the activity-dependent neuroprotective protein, modulates macrophage function.
Ann N Y Acad Sci
; 1070: 500-6, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16888216
ABSTRACT
NAP is an eight-amino acid neuroprotective peptide NAPVSIPQ; it is the smallest active element derived from the recently cloned activity-dependent neuroprotective protein (ADNP). NAP readily enters the brain from the blood. It will be important to learn whether NAP, in addition to its neuroprotective activity, also might influence immune-mediated inflammation. Here, we report that (a) macrophages express ADNP; (b) expression of ADNP in macrophages responds to VIP; and (c) NAP downregulates the key inflammatory cytokines tumor necrosis factor (TNF-alpha), interleukin-16 (IL-16), and IL-12 in macrophages. These findings indicate that ADNP/NAP can play an important role in immune regulation as well as in neuroprotection, which may be mutually related processes.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Fármacos Neuroprotetores
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha