Unchanged scrapie pathology in brain tissue of tyrosine kinase Fyn-deficient mice.
Neurodegener Dis
; 1(6): 266-8, 2004.
Article
em En
| MEDLINE
| ID: mdl-16908977
ABSTRACT
Fyn is a 59-kDa member of the Src family of tyrosine kinases synthesized on cytosolic polysomes and then targeted to the plasma membrane where it clusters in caveolae-like membrane microdomains. The cellular isoform of the prion protein (PrP) has also been identified to be a caveolar constituent and to participate in signal transduction events concerning cell survival and differentiation via recruitment of Fyn. We studied the scrapie infection of mice deficient for Fyn (Fyn(-/-)) to clarify the role of Fyn in an in vivo model of transmissible spongiforme encephalopathies. Fyn(-/-) mice died on average 9 days earlier than wild-type control mice, but no differences were seen regarding activation of astrocytes, vacuolization of the neuropil, and accumulation of misfolded prion protein. The experimental model suggests that a deficiency for Fyn is detrimental in prion diseases, although it has no major effect on the clinical course of an experimental prion infection of the CNS.
Buscar no Google
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Scrapie
/
Encéfalo
/
Proteínas PrPSc
/
Predisposição Genética para Doença
/
Proteínas Proto-Oncogênicas c-fyn
Limite:
Animals
Idioma:
En
Revista:
Neurodegener Dis
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha