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The detection and significance of minimal residual disease in acute and chronic leukemia.
Chung, N-G; Buxhofer-Ausch, V; Radich, J P.
Afiliação
  • Chung NG; Clinical Research Division, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Tissue Antigens ; 68(5): 371-85, 2006 Nov.
Article em En | MEDLINE | ID: mdl-17092250
Minimal residual disease (MRD) can be detected in many patients with leukemia who have achieved complete remission as defined by conventional pathology examination. The detection of MRD, be it by flow cytometry or by polymerase chain reaction assays, has now been found to be associated with subsequent relapses in most leukemia subtypes, either following chemotherapy or following hematopoietic stem cell transplantation. These assays are now increasingly used in clinical trial design to optimize therapy and provide a novel way to assess treatment efficacy.
Assuntos
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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Leucemia Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Neoplasia Residual / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Tissue Antigens Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Leucemia Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Neoplasia Residual / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Tissue Antigens Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Estados Unidos