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Origin and outcome of pregnancies affected by androgenetic/biparental chimerism.
Robinson, Wendy P; Lauzon, Julie L; Innes, A Micheil; Lim, Ken; Arsovska, Snezana; McFadden, Deborah E.
Afiliação
  • Robinson WP; Department of Medical Genetics, University of British Columbia, British Columbia, Canada. wprobins@interchange.ubc.ca
Hum Reprod ; 22(4): 1114-22, 2007 Apr.
Article em En | MEDLINE | ID: mdl-17185351
ABSTRACT

BACKGROUND:

Androgenetic diploid cells confined to the placenta have recently been reported in several cases of normally developed fetuses in association with placental mesenchymal dysplasia (PMD). METHODS AND

RESULTS:

We investigated two singleton, mildly growth-restricted, female pregnancies ascertained on the basis of PMD. One case had liver hemangiomas and both infants had multiple skin hemangiomas. Post-natal development was normal. Molecular marker analysis confirmed the diagnosis of androgenetic and normal mixed cell populations in the placenta. Both cases derived from a single maternal genome (M1) and two distinct paternal genomes (P1 and P2). In one case, the androgenetic cell population contained both paternal genomes (P1P2), with one shared in common with the biparental (M1P1) population. In the second case, the androgenetic lineage showed complete homozygosity (P2P2) for a paternal genome not common to the biparental cell population.

CONCLUSION:

These new PMD cases help to define the range of possible clinical presentations of androgenetic/biparental mosaicism or chimerism. Placentas with androgenetic/biparental chimeric cell populations may derive from a single tri-pronuclear (3PN) zygote in which one or more parental genomes are not equally apportioned to the daughter cells in the first cell division.
Assuntos
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Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Quimerismo / Androgênios Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: Hum Reprod Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Canadá
Buscar no Google
Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Quimerismo / Androgênios Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: Hum Reprod Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Canadá