Interstitial nephritis secondary to bevacizumab treatment in metastatic leiomyosarcoma.
Ann Pharmacother
; 41(4): 707-10, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17374619
ABSTRACT
OBJECTIVE:
To report a case of interstitial nephritis associated with the administration of bevacizumab. CASESUMMARY:
A 26-year-old man diagnosed with metastatic rectal leiomyosarcoma was treated with intravenous bevacizumab 5 mg/kg and received a total of 3 doses at 2 week intervals. His creatinine had increased from 1.0 mg/dL at baseline to 1.6 mg/dL after 2 doses of bevacizumab and to 4.7 mg/dL after the third dose, prompting admission. Acute renal failure was diagnosed, and hemodialysis was initiated. A renal biopsy revealed interstitial nephritis. Renal failure resolved with cessation of the drug, and the patient did not require further hemodialysis.DISCUSSION:
Bevacizumab is a recombinant humanized monoclonal immunoglobulin G antibody to vascular endothelial growth factor. Bevacizumab has shown efficacy in treatment of patients with renal cell carcinoma and colorectal cancer and has been approved by the Food and Drug Administration as a first-line treatment for metastatic colorectal cancer. Our patient had no other confounding factors that might have caused renal failure. The presence of primary glomerular disease was excluded by biopsy. According to the Naranjo probability scale, bevacizumab was the probable cause of acute renal failure in this patient.CONCLUSIONS:
Bevacizumab can cause acute renal failure by inducing interstitial nephritis. Renal function should be monitored during bevacizumab therapy.
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Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Colon_e_reto
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Inibidores da Angiogênese
/
Leiomiossarcoma
/
Anticorpos Monoclonais
/
Nefrite Intersticial
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Ann Pharmacother
Assunto da revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos