Early cleavage does not predict treatment outcome following the use of GnRH antagonists in women older than 35.
Fertil Steril
; 88(6): 1573-8, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17555755
ABSTRACT
OBJECTIVE:
To compare the early-cleavage rates and the implantation potential of embryos between the GnRH antagonist and agonist long stimulation protocols in women older than 35 years.DESIGN:
Retrospective analysis.SETTING:
Academic medical center. PATIENTS Two hundred twenty patients older than 35 years old underwent IVF. INTERVENTION(S) Sixty-eight patients received GnRH antagonist protocol (GnRH antagonist group) and 152 patients received GnRH agonist long stimulation protocol (GnRH agonist group). MAIN OUTCOME MEASURE(S) Early-cleavage rate of zygotes, implantation rate, and pregnancy rate. RESULT(S) Early-cleavage rate of zygotes was significantly lower in the GnRH antagonist group than agonist group (21.8% vs. 32.6%, P<.0001). In the GnRH antagonist group, the pregnancy rate was not significantly different between the early-cleavage and late-cleavage subgroups (40.0% vs. 47.4%). In the GnRH agonist group, the pregnancy rate was significantly higher in the early-cleavage subgroup than in the late-cleavage subgroup (61.0% vs. 29.8%, P<.0001). CONCLUSION(S) In women older than 35 years, the early-cleavage rate of zygotes is significantly lower in the GnRH antagonist group than the agonist group. Early-cleavage status of zygotes is not a reliable predictor for embryo implantation in patients receiving the GnRH antagonist protocol.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Hormônio Liberador de Gonadotropina
/
Fase de Clivagem do Zigoto
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Hormônio Foliculoestimulante Humano
/
Infertilidade Feminina
Tipo de estudo:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Taiwan