SUMO teams up with ubiquitin to manage hypoxia.
Cell
; 131(3): 446-7, 2007 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-17981111
ABSTRACT
Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interplay between the ubiquitin and the SUMO conjugation systems.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Ubiquitina
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
Limite:
Animals
Idioma:
En
Revista:
Cell
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido