[Human HSF1 mutants and their applications].
Sheng Wu Gong Cheng Xue Bao
; 23(6): 971-5, 2007 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-18257221
ABSTRACT
Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional activity, which dominant-negative HSF1 does not acquire. In this paper, the progress of using these HSF1 mutants in the research of cancer, neurodegenerative disorders and cardiovascular diseases will be discussed.
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Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Doenças Neurodegenerativas
/
Proteínas Mutantes
/
Proteínas de Choque Térmico
/
Neoplasias
Limite:
Humans
Idioma:
Zh
Revista:
Sheng Wu Gong Cheng Xue Bao
Assunto da revista:
BIOTECNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China