Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.
J Exp Med
; 205(7): 1635-46, 2008 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-18591411
ABSTRACT
Influenza infections induce a rapid, but transient, dendritic cell (DC) migration from the lungs to the lymph nodes (LNs) that is followed by substantial recruitment of DCs into the lungs without subsequent migration to the LNs. Given that peripheral DCs are primarily thought to be involved in the initiation of adaptive immunity after migration into lymphoid tissues, what role these newly lung-recruited DCs play in influenza virus immunity is unclear. In this study, we demonstrate that loss of non-LN migratory pulmonary DC subsets increases mortality, sustains higher viral titers, and impairs pulmonary CD8 T cell responses. Reconstitution of the lungs with pulmonary plasmacytoid DCs, CD8+ DCs, or interstitial DCs restores CD8 T cell responses in a cell contact-, major histocompatability complex I-, and influenza peptide-dependent manner. Thus, after their initial activation in the LN, protective influenza-specific CD8 T cell responses require additional antigen-dependent interactions, specifically with DCs in the lungs.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Movimento Celular
/
Infecções por Orthomyxoviridae
/
Linfócitos T CD8-Positivos
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Vírus da Influenza A Subtipo H2N2
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos