Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.
Surg Today
; 38(8): 716-25, 2008.
Article
em En
| MEDLINE
| ID: mdl-18668315
ABSTRACT
PURPOSE:
Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. BPC 157 is effective without a carrier, and it is presently undergoing trials for inflammatory bowel disease, and no toxicity has so far been reported.METHODS:
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.RESULTS:
BPC 157 improved muscle healing, macroscopically (less hematoma and edema, no post-injury leg contracture), microscopically, functionally, and also based on enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase).CONCLUSION:
BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Tendão do Calcâneo
/
Traumatismos dos Tendões
/
Cicatrização
/
Proteínas
Limite:
Animals
Idioma:
En
Revista:
Surg Today
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Croácia