Endothelial progenitor cells in adolescents: impact of overweight, age, smoking, sport and cytokines in younger age.
Clin Res Cardiol
; 98(3): 179-88, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19034379
ABSTRACT
BACKGROUND AND AIMS:
Endothelial progenitor cells (EPCs) are bone marrow derived pluripotent vascular progenitor cells capable to contribute to re-endothelialization and neovascularization. The number of circulating EPCs has been established as a biomarker of cardiovascular risk and is known to decrease with age. We determined the number of EPCs in teenagers and evaluated the influence of traditional risk factors focusing on overweight.METHODS:
79 male adolescents were enrolled (age 13-17 years; 42 of normal weight 64.1 +/- 7.6 kg; 37 above the 90th BMI-percentile 96.9 +/- 20.5 kg). 41 healthy adults served as controls. EPCs were counted by flow cytometry (CD34+/-CD133/KDR). Besides traditional risk factors, cholesterol, and high sensitive CRP different cytokines were determined.RESULTS:
Overweight adolescents have a higher systolic blood pressure, higher hsCRP, higher HbA(1c) and lower HDL. The number of CD34-negative EPCs, but not CD34-positive EPCs is higher in overweight adolescents. The overall level of EPCs is lower in adolescents compared to adults.CONCLUSIONS:
Overweight in adolescents influences EPCs in early life. CD34-negative EPCs might be more sensitive to the early risk profile and may represent a biological marker of occult vascular damage. Beginning insulin resistance, endothelial damage and elevation of EPCs could indicate the higher risk for future cardiovascular disease in obese teenagers.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Citocinas
/
Células-Tronco Pluripotentes
/
Sobrepeso
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Res Cardiol
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha