Intracerebral Mycobacterium bovis bacilli Calmette-Guerin infection-induced immune responses in the CNS.
J Neuroimmunol
; 213(1-2): 112-22, 2009 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-19535154
ABSTRACT
To study whether cerebral mycobacterial infection induces granuloma and protective immunity similar to systemic infection, we intracerebrally infected mice with Mycobacterium bovis bacilli Calmette-Guerin. Granuloma and IFN-gamma(+)CD4(+) T cell responses are induced in the central nervous system (CNS) similar to periphery, but the presence of IFN-gammaIL-17 double-positive CD4(+) T cells is unique to the CNS. The major CNS source of TNF-alpha is microglia, with modest production by CD4(+) T cells and macrophage. Protective immunity is accompanied by accumulation of Foxp3(+)CD4(+) T cells and PD-L2(+) dendritic cells, suggesting that both inflammatory and anti-inflammatory responses develop in the CNS following mycobacterial infection.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Sistema Nervoso Central
/
Encefalite
/
Granuloma
/
Mycobacterium bovis
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos