Acute neuroinflammation in Lewis rats - a model for acute multiple sclerosis relapses.
J Neuroimmunol
; 213(1-2): 84-90, 2009 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-19560215
ABSTRACT
Animal models of experimental allergic encephalomyelitis (EAE) are the most commonly used animal models for studying the pathogenesis of human multiple sclerosis (MS) as well as for target validation and compound characterization in pharmacology. By using an EAE model in Lewis rats, we focus on its neuroimmunological characterization with special attention to disease-involved cytokines, chemokines, and adhesion molecules. Furthermore, we used MR imaging to investigate macrophage infiltration and ICAM-1 expression in lesional spinal cord. Overall, due to its inflammatory character, this model is suggested to be used in early drug discovery particularly directed against acute inflammatory processes.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Encefalomielite Autoimune Experimental
/
Esclerose Múltipla
/
Mielite
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha