Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia.
Haematologica
; 95(1): 158-62, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19586936
ABSTRACT
Although deletions of cell cycle regulatory gene loci have long been reported in various malignancies, little is known regarding their relevance in pediatric T-cell lymphoblastic lymphoma (T-LBL) and T-cell lymphoblastic leukemia (TALL). The current study focused on loss of heterozygosity (LOH) analyses of the CDKN2A/B (chromosome 9p), ATM (chromosome 11q) and p53 (chromosome 17p) gene loci. Frequencies of LOH were compared in 113 pediatric T-LBL and 125 T-ALL who were treated uniformly according to ALL-BFM strategies. Furthermore, LOH findings were correlated with clinical characteristics and tested for their prognostic relevance. LOH at 9p was detected in 47% of T-LBL and 51% of T-ALL, and was associated with male gender in both. In T-ALL, LOH at 9p was associated with favorable initial treatment response. A tendency for favorable event-free-survival was observed in LOH 9p positive T-LBL. The frequency of LOH at chromosomes 11q and 17p was 5% or less for both diseases.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Leucemia
Base de dados:
MEDLINE
Assunto principal:
Leucemia de Células T
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Proteína Supressora de Tumor p53
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Proteínas Serina-Treonina Quinases
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Proteínas de Ciclo Celular
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Repetições de Microssatélites
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Inibidor p16 de Quinase Dependente de Ciclina
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Proteínas Supressoras de Tumor
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Proteínas de Ligação a DNA
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Inibidor de Quinase Dependente de Ciclina p15
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Haematologica
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha