Oesophageal ulceration after selective internal radiation therapy in a patient with carcinoma of unknown primary.
Z Gastroenterol
; 48(5): 546-50, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20449787
ABSTRACT
BACKGROUND:
Cancer of unknown primary (CUP) is defined as histologically confirmed metastases in the absence of an identifiable primary tumor. Patients with solely liver metastases from adenocarinomas represent the most frequent subgroup with an unfavourable prognosis. The medium survival averages 6 to 9 months. No chemotherapheutic standard has been established. CASE We present a patient with hepatic CUP. After cycles of chemotherapy and hemihepatectomy the tumor returned and showed hepatic progression. The patient was evaluated for selective internal radiation therapy (SIRT). Three years after diagnosis she is still alive and tumorfree. Despite a good result and disease control our patient suffered radiation-induced ulceration in the oesophagus, stomach, and duodenum. This side effect appears in up to 12 % of patients, often very late after treatment, is refractory to pharmacotherapy and persistent over a long time.CONCLUSIONS:
SIRT is a new, effective treatment in patients with hepatic CUP. Because of the anticipated increase of this therapy, adverse side effects such as ulcerations in the upper-GI tract secondary to ectopic implantation of microspheres may be seen more commonly. Awareness of this and the recognition of microspheres in biopsies is cardinal for appropriate management and maintenance of the patient's quality of life.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Prevencao_e_fatores_de_risco
/
Agentes_cancerigenos
/
Tipos_de_cancer
/
Outros_tipos
/
Tratamento
/
Radioterapia
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
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Úlcera Gástrica
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Úlcera
/
Neoplasias Primárias Desconhecidas
/
Braquiterapia
/
Adenocarcinoma
/
Úlcera Duodenal
/
Embolização Terapêutica
/
Doenças do Esôfago
/
Esôfago
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Z Gastroenterol
Ano de publicação:
2010
Tipo de documento:
Article