Vitamin D: metabolism.
Endocrinol Metab Clin North Am
; 39(2): 243-53, table of contents, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20511049
The biologically active metabolite of vitamin D, 1,25(OH)(2)D(3), affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH)(2)D(3). The role of extrarenal 1alpha(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Esteroide Hidroxilases
/
Vitamina D
/
Proteína de Ligação a Vitamina D
/
Deficiência de Vitamina D
/
Colecalciferol
/
Colestanotriol 26-Mono-Oxigenase
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Endocrinol Metab Clin North Am
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos