Histone H1 poly[ADP]-ribosylation regulates the chromatin alterations required for learning consolidation.
J Neurosci
; 30(40): 13305-13, 2010 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-20926656
ABSTRACT
Memory formation requires changes in gene expression, which are regulated by the activation of transcription factors and by changes in epigenetic factors. Poly[ADP]-ribosylation of nuclear proteins has been postulated as a chromatin modification involved in memory consolidation, although the mechanisms involved are not well characterized. Here we demonstrate that poly[ADP]-ribose polymerase 1 (PARP-1) activity and the poly[ADP]-ribosylation of proteins over a specific time course is required for the changes in synaptic plasticity related to memory stabilization in mice. At the molecular level, histone H1 poly[ADP]-ribosylation was evident in the hippocampus after the acquisition period, and it was selectively released in a PARP-1-dependent manner at the promoters of cAMP response element-binding protein and nuclear factor-κB dependent genes associated with learning and memory. These findings suggest that histone H1 poly[ADP]-ribosylation, and its loss at specific loci, is an epigenetic mechanism involved in the reprogramming of neuronal gene expression required for memory consolidation.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Poli Adenosina Difosfato Ribose
/
Cromatina
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Histonas
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Proteínas
/
Aprendizagem
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha